TSPAN19

Across TCGA patient cohorts, TSPAN19 mutation is significantly associated with the RNA expression of many other genes, with 671 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN19-associated genes across cancer lineages are IGHD2-2, PGBD4P2, and MIR6738. Each is linked with TSPAN19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN19-to-partner and partner-to-TSPAN19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD2-2 grouped by TSPAN19-low versus TSPAN19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN19→partner) and Y-score (partner→TSPAN19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD2-2 →	+1.411	+1.819	<.001	.008	3	2
READ	PGBD4P2 →	+0.121	+5.257	<.001	.002	3	1
READ	MIR6738 →	+1.071	+4.361	<.001	.006	3	1
UCEC	AKAP5 →	+0.572	+2.906	<.001	.002	3	1
UCEC	HARBI1 →	+0.441	+3.353	.001	.005	3	1
UCEC	PRF1 →	+1.300	+3.815	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 671 associations by consensus.

IGHD2-2 by TSPAN19 expression — UCEC

Explore this box plot interactively →