TSPAN19

Across TCGA pan-cancer cohorts, TSPAN19 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSPAN19’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TSPAN19 RNA is repressed in tumor relative to normal tissue. In most cancer types TSPAN19 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where TSPAN19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPAN19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.710	<.001	11	view →
KICH	Male	All	−0.259	<.001	10	view →
LUSC	Female	All	−1.518	<.001	8	view →
LUAD	All	All	−0.928	<.001	8	view →
BRCA	All	All	−0.055	<.001	6	view →
KIRP	All	All	+0.225	.002	5	view →
READ	All	All	−0.076	.025	4	view →
STAD	All	All	−0.022	.037	3	view →
PRAD	All	All	+0.476	<.001	2	view →
UCEC	All	All	−0.176	.001	2	view →
COAD	Female	IV	−0.025	.037	2	view →
LIHC	All	All	+0.003	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TSPAN19–THCA

Open the THCA breakdown →