TSPAN19

Across TCGA patient cohorts, TSPAN19 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN19-associated genes across cancer lineages are p62 Lck ligand, MSH6, and PDK1_pS241. Each is linked with TSPAN19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN19-to-partner and partner-to-TSPAN19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by TSPAN19-low versus TSPAN19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN19→partner) and Y-score (partner→TSPAN19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.623	+3.594	<.001	.001	3	2
UCEC	MSH6 →	-0.450	-2.999	.004	.035	3	1
UCEC	PDK1_pS241 →	+0.262	+3.321	.001	.010	3	1
UCEC	Rab11 →	-0.149	-2.459	.033	.020	3	1
UCEC	Annexin-1 →	+0.576	+3.189	.023	.010	3	1
UCEC	CDK1_pY15 →	+0.208	+2.343	.046	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

p62 Lck ligand by TSPAN19 expression — UCEC

Explore this box plot interactively →