TSPAN17

Across TCGA patient cohorts, TSPAN17 mutation is significantly associated with the RNA expression of many other genes, with 1,418 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN17-associated genes across cancer lineages are CDCA2, PCCB, and MRPL37. Each is linked with TSPAN17 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSPAN17-to-partner and partner-to-TSPAN17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA2 grouped by TSPAN17-low versus TSPAN17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN17→partner) and Y-score (partner→TSPAN17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA2 →	+0.921	+2.502	<.001	.002	3	3
UCEC	PCCB →	+0.485	+3.475	.006	.002	3	3
UCEC	MRPL37 →	+0.433	+2.748	.006	.003	3	3
UCEC	SCO1 →	+0.572	+2.513	<.001	.001	3	3
LUSC	GAGE12H →	+0.395	+5.273	.006	.006	3	2
LUAD	MIR4253 →	+0.479	+5.279	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,418 associations by consensus.

CDCA2 by TSPAN17 expression — UCEC

Explore this box plot interactively →