TSPAN17

Across TCGA pan-cancer cohorts, TSPAN17 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TSPAN17 data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher TSPAN17 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TSPAN17 expression acts as an unfavorable survival marker, although some lineages such as STAD and SCLC show a favorable association.

UVM, KICH, and HNSC are the cancer types where TSPAN17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.404	0.766	<.001	106	view →
KICH	OS	Median	II,III,IV	0.594	1.000	<.001	104	view →
HNSC	OS	Median	III,IV	0.393	0.683	<.001	84	view →
LGG	DFS	Median	All	0.664	0.808	<.001	50	view →
MESO	DFS	Median	II,III,IV	0.230	0.670	.001	45	view →
STAD	DFS	Quartile	II,III,IV	0.727	0.508	.005	42	view →
ACC	DFS	Quartile	All	0.242	0.849	<.001	42	view →
LIHC	DFS	Median	All	0.363	0.504	<.001	37	view →
SCLC	OS	Median	II,III,IV	1.000	0.462	.012	12	view →
CESC	OS	Median	IV	0.544	0.181	.032	12	view →
PRAD	DFS	Tertile	All	0.881	0.973	.002	12	view →
READ	DFS	Quartile	All	0.944	0.556	.007	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TSPAN17–UVM (OS)

Open the UVM breakdown →