TSPAN17

Across TCGA patient cohorts, TSPAN17 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN17-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and PDK1_pS241. Each is linked with TSPAN17 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN17-to-partner and partner-to-TSPAN17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TSPAN17-low versus TSPAN17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN17→partner) and Y-score (partner→TSPAN17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.706	+2.341	.003	.019	3	2
UCEC	Cyclin-B1 →	+0.616	+2.321	.007	.006	3	2
UCEC	PDK1_pS241 →	+0.186	+3.196	.008	.009	3	1
UCEC	Rab11 →	-0.124	-1.980	.038	.030	3	1
UCEC	STAT3_pY705 →	-0.298	-2.449	.005	.019	3	1
UCEC	Caspase-8 →	-0.270	-2.558	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Caspase-7-cleavedD198 by TSPAN17 expression — UCEC

Explore this box plot interactively →