TSPAN12

Across TCGA patient cohorts, TSPAN12 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN12-associated genes across cancer lineages are PREX1, C-Raf, and EGFR_pY1068. Each is linked with TSPAN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN12-to-partner and partner-to-TSPAN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREX1 grouped by TSPAN12-low versus TSPAN12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN12→partner) and Y-score (partner→TSPAN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PREX1 →	-0.266	-3.169	.022	.018	3	2
UCEC	C-Raf →	+0.210	+2.000	<.001	.030	3	2
UCEC	EGFR_pY1068 →	-0.231	-1.700	.030	.044	3	1
UCEC	FASN →	+0.468	+2.222	.005	.011	3	1
UCEC	FoxM1 →	+0.286	+2.179	.009	.034	3	1
UCEC	IGFBP2 →	-0.592	-2.999	.032	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PREX1 by TSPAN12 expression — UCEC

Explore this box plot interactively →