TSPAN12

Across TCGA pan-cancer cohorts, TSPAN12 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSPAN12’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TSPAN12 RNA is repressed in tumor relative to normal tissue. In most cancer types TSPAN12 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where TSPAN12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPAN12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.208	<.001	11	view →
KICH	Male	II,III,IV	−3.321	<.001	10	view →
LUSC	Female	II,III,IV	−3.702	<.001	9	view →
LUAD	Female	III,IV	−1.975	<.001	9	view →
LIHC	All	All	−0.656	.002	6	view →
HNSC	All	All	−0.877	<.001	4	view →
BRCA	All	All	−0.665	<.001	4	view →
CHOL	All	All	+1.567	.001	3	view →
READ	All	II,III,IV	−1.097	.019	3	view →
UCEC	All	All	−0.853	.039	2	view →
PRAD	All	All	−0.621	<.001	2	view →
KIRC	Female	All	+0.602	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TSPAN12–THCA

Open the THCA breakdown →