TSPAN12

Across TCGA cell cohorts, TSPAN12 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TSPAN12-associated genes across cancer lineages are DCANP1, SMIM28, and GPR26. Each is linked with TSPAN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN12-to-partner and partner-to-TSPAN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCANP1 grouped by TSPAN12-low versus TSPAN12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN12→partner) and Y-score (partner→TSPAN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCANP1 →	+0.010	+4.347	<.001	.001	3	1
LARGE_INTESTINE	SMIM28 →	+0.016	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	GPR26 →	+0.016	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRY →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRY2 →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	NLRP8 →	+0.054	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

DCANP1 by TSPAN12 expression — LARGE_INTESTINE

Explore this box plot interactively →