TSPAN1

Across TCGA patient cohorts, TSPAN1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN1-associated genes across cancer lineages are Notch1, c-Met_pY1235, and Lck. Each is linked with TSPAN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN1-to-partner and partner-to-TSPAN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TSPAN1-low versus TSPAN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN1→partner) and Y-score (partner→TSPAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.230	+2.817	.004	.036	3	1
UCEC	c-Met_pY1235 →	+0.108	+2.817	.012	.036	3	1
UCEC	Lck →	+0.252	+3.000	.030	.037	2	1
UCEC	PCNA →	+0.273	+3.000	.029	.037	2	1
UCEC	VHL →	-1.124	-3.000	.004	.036	2	1
UCEC	c-Jun_pS73 →	-0.198	-3.000	.031	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by TSPAN1 expression — UCEC

Explore this box plot interactively →