TSPAN1

Across TCGA pan-cancer cohorts, TSPAN1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSPAN1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TSPAN1 RNA is repressed in tumor relative to normal tissue. In most cancer types TSPAN1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and KIRC are the cancer types where TSPAN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPAN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−2.307	<.001	12	view →
KICH	All	III,IV	−3.880	<.001	11	view →
KIRC	Male	III,IV	−1.712	<.001	11	view →
BRCA	All	III,IV	+2.161	<.001	6	view →
THCA	Female	II,III,IV	−1.618	<.001	6	view →
READ	All	All	−2.426	<.001	5	view →
PAAD	All	All	+4.322	.013	2	view →
STAD	Male	IV	−2.260	.013	2	view →
CHOL	Male	All	+2.201	<.001	2	view →
STAD	Male	All	+1.959	.031	2	view →
PRAD	All	All	+1.379	<.001	2	view →
LUSC	All	II,III,IV	−1.126	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TSPAN1–COAD

Open the COAD breakdown →