TSNAX

Across TCGA pan-cancer cohorts, TSNAX mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TSNAX data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TSNAX mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSNAX expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where TSNAX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.399	0.916	.017	14	view →
LUAD	DFS	Tertile	II,III,IV	0.866	0.313	.018	8	view →
PDAC	OS	Tertile	III,IV	0.965	0.472	.013	7	view →
LSCC	OS	Median	All	0.873	0.706	.023	3	view →
GBM	OS	Median	All	0.440	0.305	.023	2	view →
HNSC	DFS	Quartile	III,IV	0.951	0.696	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TSNAX–UCEC (DFS)

Open the UCEC breakdown →