TSNAX

Across TCGA patient cohorts, TSNAX mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSNAX-associated genes across cancer lineages are Fibronectin, JNK2, and Ku80. Each is linked with TSNAX in more than 1 cancer types. Because this analysis shows association rather than direction, both TSNAX-to-partner and partner-to-TSNAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by TSNAX-low versus TSNAX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSNAX→partner) and Y-score (partner→TSNAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.341	-3.312	.026	.010	3	1
UCEC	JNK2 →	+0.256	+2.584	.005	.011	3	1
UCEC	Ku80 →	+0.238	+2.820	.030	.035	3	1
UCEC	VHL →	-1.087	-2.584	<.001	.011	3	1
UCEC	Bax →	+0.282	+2.999	.011	.035	3	1
UCEC	4E-BP1 →	+0.304	+2.199	.016	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Fibronectin by TSNAX expression — UCEC

Explore this box plot interactively →