TSLP

Across TCGA cell cohorts, TSLP RNA expression is significantly associated with the go_rna of many other GO terms, with 2,706 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSLP-associated GO terms across cancer lineages are Positive regulation of mast cell activation, Negative regulation of myoblast fusion, and Response to endoplasmic reticulum stress. Each is linked with TSLP in more than 10 cancer types. Because this analysis shows association rather than direction, both TSLP-to-partner and partner-to-TSLP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mast cell activation grouped by TSLP-low versus TSLP-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSLP→partner) and Y-score (partner→TSLP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of mast cell activation →	-0.260	-0.644	.007	.001	3	11
STOMACH	Negative regulation of myoblast fusion →	+0.106	+0.204	.001	.009	3	9
LUNG_NSCLC_LUAD	Response to endoplasmic reticulum stress →	+0.041	+0.411	<.001	.007	3	8
BREAST	T-helper 17 cell differentiation →	+0.107	+0.508	<.001	<.001	3	7
STOMACH	Regulation of proteasomal protein catabolic process →	+0.053	+0.147	.002	.009	2	8
PANCREAS	Regulation of protein exit from endoplasmic reticulum →	+0.087	+0.413	.003	.007	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,706 associations by consensus.

Positive regulation of mast cell activation by TSLP expression — BREAST

Explore this box plot interactively →