TSKU

Across TCGA pan-cancer cohorts, TSKU mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TSKU data layer compared with 31 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TSKU mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TSKU expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where TSKU mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.612	0.858	.001	41	view →
CCRCC	DFS	Tertile	III,IV	0.272	0.932	<.001	36	view →
PDAC	DFS	Median	II,III,IV	0.233	0.461	.021	3	view →
LSCC	OS	Tertile	All	1.000	0.935	.046	1	view →
HNSC	DFS	Median	IV	0.915	1.000	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TSKU–LUAD (OS)

Open the LUAD breakdown →