TSKU

Across TCGA pan-cancer cohorts, TSKU mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TSKU’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TSKU mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TSKU is over-expressed in tumor, although a few such as LUAD and OV show the opposite, repressed pattern.

LUAD, LSCC, and CCRCC are the cancer types where TSKU tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSKU mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.459	<.001	9	view →
LSCC	All	All	+0.237	<.001	7	view →
CCRCC	Female	IV	+0.916	.026	3	view →
OV	All	All	−1.057	.041	2	view →
PDAC	All	All	+0.338	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TSKU–LUAD

Open the LUAD breakdown →