TSKS

Across TCGA patient cohorts, TSKS mutation is significantly associated with the RNA expression of many other genes, with 2,847 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSKS-associated genes across cancer lineages are MYO19, PDSS1P2, and WDR7-OT1. Each is linked with TSKS in more than 3 cancer types. Because this analysis shows association rather than direction, both TSKS-to-partner and partner-to-TSKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO19 grouped by TSKS-low versus TSKS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSKS→partner) and Y-score (partner→TSKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO19 →	+0.498	+2.392	<.001	<.001	3	4
COAD	PDSS1P2 →	+0.268	+2.370	<.001	.007	3	3
LUAD	WDR7-OT1 →	+0.149	+3.270	<.001	.001	3	3
UCEC	SGSM3 →	+0.399	+2.403	.003	<.001	3	3
UCEC	CEP76 →	+0.387	+2.010	.003	.001	3	3
UCEC	SGO1 →	+0.705	+3.849	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,847 associations by consensus.

MYO19 by TSKS expression — UCEC

Explore this box plot interactively →