TSKS

Across TCGA pan-cancer cohorts, TSKS RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TSKS data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TSKS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSKS expression acts as an unfavorable survival marker, although some lineages such as CESC and HNSC show a favorable association.

KIRC, COAD, and CESC are the cancer types where TSKS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.498	0.707	.003	66	view →
COAD	DFS	Median	All	0.368	0.612	.002	33	view →
CESC	OS	Tertile	All	0.912	0.818	.018	32	view →
HNSC	DFS	Tertile	IV	0.563	0.305	.004	28	view →
ACC	DFS	Quartile	All	0.340	0.903	.011	23	view →
LGG	DFS	Quartile	All	0.609	0.790	<.001	23	view →
ESCA	OS	Median	IV	0.698	0.222	.006	18	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	15	view →
OV	OS	Quartile	All	0.766	0.896	.007	12	view →
BLCA	DFS	Tertile	II,III,IV	0.465	0.563	.022	11	view →
THCA	OS	Quartile	III,IV	0.692	1.000	.004	8	view →
GBM	OS	Median	All	0.154	0.212	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

TSKS–KIRC (DFS)

Open the KIRC breakdown →