TSKS

Across TCGA patient cohorts, TSKS mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSKS-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and IRS1. Each is linked with TSKS in more than 4 cancer types. Because this analysis shows association rather than direction, both TSKS-to-partner and partner-to-TSKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TSKS-low versus TSKS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSKS→partner) and Y-score (partner→TSKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.078	+2.824	.005	.034	3	5
UCEC	A-Raf_pS299 →	-0.100	-2.222	.022	.010	3	2
UCEC	IRS1 →	+0.185	+1.502	.015	.030	3	2
UCEC	ATM →	-0.511	-1.847	.002	.008	3	2
UCEC	4E-BP1 →	+0.294	+2.145	.003	.009	2	3
UCEC	FoxM1 →	+0.200	+2.247	.035	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by TSKS expression — COAD

Explore this box plot interactively →