TSIX

Across TCGA patient cohorts, TSIX RNA expression is significantly associated with the go_rna of many other GO terms, with 6,949 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TSIX-associated GO terms across cancer lineages are Centrosome duplication, Protein demethylation, and tRNA modification. Each is linked with TSIX in more than 25 cancer types. Because this analysis shows association rather than direction, both TSIX-to-partner and partner-to-TSIX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome duplication grouped by TSIX-low versus TSIX-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSIX→partner) and Y-score (partner→TSIX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Centrosome duplication →	+0.087	+0.046	<.001	.002	2	25
DLBC	Protein demethylation →	+0.096	+0.031	.001	.008	1	26
STAD	tRNA modification →	+0.053	+0.028	<.001	<.001	3	24
STAD	Obsolete histone modification →	+0.059	+0.033	<.001	<.001	3	24
STAD	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.071	+0.030	<.001	<.001	3	24
STAD	Regulation of telomere maintenance →	+0.064	+0.033	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,949 associations by consensus.

Centrosome duplication by TSIX expression — ESCA

Explore this box plot interactively →