TSIX

Across TCGA patient cohorts, TSIX mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSIX-associated genes across cancer lineages are PREX1, ASNS, and EGFR_pY1173. Each is linked with TSIX in more than 2 cancer types. Because this analysis shows association rather than direction, both TSIX-to-partner and partner-to-TSIX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREX1 grouped by TSIX-low versus TSIX-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSIX→partner) and Y-score (partner→TSIX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PREX1 →	+0.201	+3.013	.011	.018	3	3
STAD	ASNS →	+0.606	+3.169	.005	.019	3	3
UCEC	EGFR_pY1173 →	+0.044	+1.584	.046	.032	3	3
UCEC	TFRC →	+0.401	+2.807	.006	.002	3	3
UCEC	Cyclin-B1 →	+0.601	+2.807	<.001	<.001	3	3
LUSC	Caspase-7-cleavedD198 →	+0.515	+2.009	.010	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

PREX1 by TSIX expression — LUSC

Explore this box plot interactively →