TSHZ3

Across TCGA pan-cancer cohorts, TSHZ3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated TSHZ3 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TSHZ3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TSHZ3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, UCEC, and DLBC are the cancer types where TSHZ3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.141	0.772	<.001	24	view →
UCEC	DFS	Median	All	0.788	0.614	.004	18	view →
DLBC	DFS	Median	III,IV	0.137	0.790	<.001	15	view →
LAML	DFS	Median	All	0.028	0.572	<.001	12	view →
ESCA	OS	Median	IV	0.095	0.512	.008	12	view →
HNSC	OS	Median	II,III,IV	0.174	0.711	.016	9	view →
CESC	OS	Median	III,IV	0.167	0.657	.044	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
LUAD	DFS	Median	IV	0.047	0.565	<.001	6	view →
LGG	OS	Median	All	0.218	0.830	.014	5	view →
STAD	DFS	Median	III,IV	0.188	0.451	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

TSHZ3–KIRP (OS)

Open the KIRP breakdown →