TSHZ3

Across TCGA pan-cancer cohorts, TSHZ3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TSHZ3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSHZ3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSHZ3 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where TSHZ3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSHZ3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+1.602	<.001	12	view →
THCA	Male	III,IV	−1.810	<.001	10	view →
BLCA	Male	IV	−1.992	.003	7	view →
COAD	All	II,III,IV	−0.711	<.001	7	view →
UCEC	All	All	−3.231	<.001	6	view →
BRCA	All	All	−0.315	.001	4	view →
STAD	Female	All	−1.472	.013	2	view →
PRAD	All	All	−0.780	<.001	2	view →
KIRP	All	All	−0.557	.002	2	view →
READ	Female	All	−1.694	.020	1	view →
CHOL	All	All	+0.855	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TSHZ3–HNSC

Open the HNSC breakdown →