TSHZ3

Across TCGA patient cohorts, TSHZ3 mutation is significantly associated with the RNA expression of many other genes, with 7,730 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSHZ3-associated genes across cancer lineages are SMC3, KIF20A, and MAD2L1. Each is linked with TSHZ3 in more than 4 cancer types. Because this analysis shows association rather than direction, both TSHZ3-to-partner and partner-to-TSHZ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMC3 grouped by TSHZ3-low versus TSHZ3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHZ3→partner) and Y-score (partner→TSHZ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SMC3 →	+0.570	+1.857	.004	.004	3	5
UCEC	KIF20A →	+0.497	+1.126	<.001	<.001	3	5
UCEC	MAD2L1 →	+0.752	+1.928	<.001	<.001	3	5
UCEC	SEH1L →	+0.326	+1.688	<.001	<.001	3	5
LUSC	MAPK10 →	-0.753	-3.584	<.001	.002	3	5
UCEC	CCDC43 →	+0.494	+1.617	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,730 associations by consensus.

SMC3 by TSHZ3 expression — SKCM

Explore this box plot interactively →