TSHZ3

Across TCGA cell cohorts, TSHZ3 mutation is significantly associated with the RNA expression of many other genes, with 805 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSHZ3-associated genes across cancer lineages are C8orf74, ZNF804B, and DLG3. Each is linked with TSHZ3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSHZ3-to-partner and partner-to-TSHZ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8orf74 grouped by TSHZ3-low versus TSHZ3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHZ3→partner) and Y-score (partner→TSHZ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C8orf74 →	+0.165	+3.502	.003	.007	3	2
OESOPHAGUS	ZNF804B →	+0.019	+4.017	<.001	.007	3	2
BLOOD_Leukemia	DLG3 →	+1.475	+3.120	.005	.009	3	2
LUNG_NSCLC_LUAD	ZNF837 →	-0.395	-2.469	.001	.004	3	2
LARGE_INTESTINE	FANCE →	+0.408	+2.222	.002	.001	3	2
LARGE_INTESTINE	TTC33 →	+0.580	+2.584	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 805 associations by consensus.

C8orf74 by TSHZ3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →