TSHZ3

Across TCGA cell cohorts, TSHZ3 mutation is significantly associated with the mutation status of many other genes, with 4,192 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSHZ3-associated genes across cancer lineages are MYO7A, RIMBP2, and PDZD2. Each is linked with TSHZ3 in more than 6 cancer types. Because this analysis shows association rather than direction, both TSHZ3-to-partner and partner-to-TSHZ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO7A grouped by TSHZ3-low versus TSHZ3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHZ3→partner) and Y-score (partner→TSHZ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MYO7A →	+3.930	+3.632	.003	.003	1	7
BLOOD_Leukemia	RIMBP2 →	+1.959	+1.847	.009	.009	1	6
SKIN	PDZD2 →	+2.070	+2.432	.003	.003	1	6
OVARY	DOT1L →	+3.345	+3.345	.007	.007	1	6
OVARY	DNAH1 →	+2.538	+3.347	.005	.005	1	6
OVARY	CABIN1 →	+3.930	+3.632	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,192 associations by consensus.

MYO7A by TSHZ3 expression — OVARY

Explore this box plot interactively →