TSHZ2

Across TCGA patient cohorts, TSHZ2 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSHZ2-associated genes across cancer lineages are CD31, ATM, and PCNA. Each is linked with TSHZ2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSHZ2-to-partner and partner-to-TSHZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD31 grouped by TSHZ2-low versus TSHZ2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHZ2→partner) and Y-score (partner→TSHZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CD31 →	-0.140	-2.213	.032	.010	3	3
UCEC	ATM →	-0.687	-2.115	<.001	<.001	3	3
UCEC	PCNA →	+0.181	+1.584	.007	.005	3	3
UCEC	Caspase-7-cleavedD198 →	+0.455	+1.926	.014	.008	3	3
STAD	P-Cadherin →	-0.201	-3.169	.004	.019	3	2
BRCA	4E-BP1_pS65 →	+0.368	+3.176	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

CD31 by TSHZ2 expression — LUSC

Explore this box plot interactively →