TSHZ2

Across TCGA pan-cancer cohorts, TSHZ2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSHZ2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TSHZ2 RNA is repressed in tumor relative to normal tissue. In most cancer types TSHZ2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where TSHZ2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSHZ2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.145	<.001	9	view →
THCA	Male	All	−0.872	<.001	8	view →
LIHC	All	II,III,IV	+0.726	<.001	7	view →
BRCA	All	All	−2.206	<.001	6	view →
UCEC	All	All	−1.527	<.001	6	view →
BLCA	All	III,IV	−0.817	.003	6	view →
LUAD	All	II,III,IV	+0.615	<.001	6	view →
LUSC	All	II,III,IV	+0.846	<.001	5	view →
CHOL	Male	All	+1.676	<.001	4	view →
PRAD	All	All	−0.446	.004	2	view →
READ	Female	All	−1.115	.026	1	view →
ESCA	All	All	−0.797	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TSHZ2–KICH

Open the KICH breakdown →