TSHZ2

Across TCGA cell cohorts, TSHZ2 mutation is significantly associated with the RNA expression of many other genes, with 459 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSHZ2-associated genes across cancer lineages are CLEC2B, COX4I2, and MTRNR2L6. Each is linked with TSHZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSHZ2-to-partner and partner-to-TSHZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC2B grouped by TSHZ2-low versus TSHZ2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHZ2→partner) and Y-score (partner→TSHZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CLEC2B →	-1.398	-3.321	<.001	.003	3	2
BLOOD_Leukemia	COX4I2 →	+0.522	+4.276	<.001	.007	3	2
BLOOD_Leukemia	MTRNR2L6 →	+0.088	+5.269	<.001	<.001	3	2
LARGE_INTESTINE	PDZD11 →	-0.418	-1.956	.006	.002	3	2
LARGE_INTESTINE	RAB3IP →	+0.474	+3.169	.005	.009	3	2
LARGE_INTESTINE	FRA10AC1 →	+0.522	+2.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 459 associations by consensus.

CLEC2B by TSHZ2 expression — SKIN

Explore this box plot interactively →