TSHZ1

Across TCGA patient cohorts, TSHZ1 mutation is significantly associated with the RNA expression of many other genes, with 5,869 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSHZ1-associated genes across cancer lineages are ACBD5, RNU6-178P, and MIR769. Each is linked with TSHZ1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TSHZ1-to-partner and partner-to-TSHZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACBD5 grouped by TSHZ1-low versus TSHZ1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHZ1→partner) and Y-score (partner→TSHZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACBD5 →	+0.619	+3.625	<.001	.001	3	4
LUSC	RNU6-178P →	+0.306	+2.427	.004	.006	3	3
LUSC	MIR769 →	+0.262	+2.639	<.001	.009	3	3
LUSC	MIR6783 →	+0.497	+2.376	.004	.007	3	3
UCEC	MYO19 →	+0.392	+1.509	<.001	<.001	3	3
COAD	POLH-AS1 →	+0.536	+3.740	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,869 associations by consensus.

ACBD5 by TSHZ1 expression — COAD

Explore this box plot interactively →