TSHR

Across TCGA pan-cancer cohorts, TSHR Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TSHR data layer compared with 30 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TSHR Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TSHR expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, ESCA, and HNSC are the cancer types where TSHR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.967	0.824	.006	34	view →
ESCA	OS	Median	II,III,IV	0.117	0.703	<.001	24	view →
HNSC	DFS	Median	All	0.140	0.627	.002	22	view →
COAD	OS	Median	All	0.481	0.811	<.001	21	view →
READ	OS	Median	III,IV	0.287	0.748	.001	12	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
BLCA	OS	Median	IV	0.193	0.598	.047	3	view →
SKCM	DFS	Median	All	0.967	0.713	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TSHR–UCEC (DFS)

Open the UCEC breakdown →