TSHR

Across TCGA patient cohorts, TSHR mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSHR-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and Chk1. Each is linked with TSHR in more than 2 cancer types. Because this analysis shows association rather than direction, both TSHR-to-partner and partner-to-TSHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TSHR-low versus TSHR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHR→partner) and Y-score (partner→TSHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.325	+1.321	.002	.027	3	3
UCEC	Caspase-7-cleavedD198 →	+0.658	+1.857	<.001	<.001	3	3
SKCM	Chk1 →	+0.375	+1.356	<.001	.043	3	2
UCEC	eIF4E →	+0.158	+1.857	.010	<.001	3	2
UCEC	GAPDH →	+0.375	+1.440	.017	.022	3	2
UCEC	IGFBP2 →	-0.603	-1.415	.001	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ASNS by TSHR expression — UCEC

Explore this box plot interactively →