TSHR

Across TCGA cell cohorts, TSHR RNA expression is significantly associated with the go_rna of many other GO terms, with 2,474 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSHR-associated GO terms across cancer lineages are Cellular response to glycoprotein, Aromatic amino acid family catabolic process, and Negative regulation of myoblast fusion. Each is linked with TSHR in more than 9 cancer types. Because this analysis shows association rather than direction, both TSHR-to-partner and partner-to-TSHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to glycoprotein grouped by TSHR-low versus TSHR-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHR→partner) and Y-score (partner→TSHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Cellular response to glycoprotein →	+1.909	+2.767	<.001	<.001	3	10
STOMACH	Aromatic amino acid family catabolic process →	-0.164	-0.314	<.001	.009	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.091	+0.083	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.086	+0.083	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.093	+0.096	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.128	+0.138	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,474 associations by consensus.

Cellular response to glycoprotein by TSHR expression — BLOOD_Myeloma

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