TSHR

Across TCGA cell cohorts, TSHR mutation is significantly associated with the RNA expression of many other genes, with 926 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSHR-associated genes across cancer lineages are GPR42, SMIM28, and REG1B. Each is linked with TSHR in more than 1 cancer types. Because this analysis shows association rather than direction, both TSHR-to-partner and partner-to-TSHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR42 grouped by TSHR-low versus TSHR-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHR→partner) and Y-score (partner→TSHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SMIM28 →	+0.048	+5.228	<.001	.005	3	1
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1
LARGE_INTESTINE	ANKRD54 →	+0.550	+3.237	<.001	.003	3	1
LARGE_INTESTINE	EIF3L →	+0.559	+3.389	<.001	.001	3	1
LARGE_INTESTINE	CCDC134 →	+0.633	+2.502	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 926 associations by consensus.

GPR42 by TSHR expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →