TSG101

Across TCGA pan-cancer cohorts, TSG101 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TSG101’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where TSG101 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TSG101 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

PDAC, LUAD, and HNSC are the cancer types where TSG101 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSG101 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+0.560	<.001	9	view →
LUAD	Male	II,III,IV	+0.260	<.001	8	view →
HNSC	All	IV	−0.240	<.001	8	view →
CCRCC	Male	All	−0.050	.025	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TSG101–PDAC

Open the PDAC breakdown →