TSG101

Across TCGA pan-cancer cohorts, TSG101 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TSG101 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TSG101 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TSG101 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

HNSC, LIHC, and KIRC are the cancer types where TSG101 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.387	0.704	<.001	118	view →
LIHC	OS	Tertile	All	0.587	0.772	<.001	90	view →
KIRC	OS	Tertile	All	0.753	0.544	<.001	87	view →
ACC	DFS	Median	All	0.225	0.661	<.001	64	view →
BRCA	DFS	Quartile	III,IV	0.941	0.794	.003	28	view →
PAAD	OS	Quartile	All	0.440	0.770	.006	27	view →
MESO	DFS	Median	II,III,IV	0.303	0.597	.013	24	view →
CESC	DFS	Median	IV	0.089	0.389	.039	18	view →
STAD	OS	Quartile	All	0.262	0.650	.003	18	view →
LGG	DFS	Tertile	All	0.650	0.356	.002	16	view →
SKCM	OS	Quartile	All	0.421	0.223	.003	15	view →
COAD	DFS	Tertile	All	0.647	0.786	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TSG101–HNSC (OS)

Open the HNSC breakdown →