TSG101

Across TCGA patient cohorts, TSG101 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSG101-associated genes across cancer lineages are PCNA, Cyclin-B1, and eEF2. Each is linked with TSG101 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSG101-to-partner and partner-to-TSG101 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TSG101-low versus TSG101-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSG101→partner) and Y-score (partner→TSG101) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.249	+2.736	.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.664	+3.459	.001	.005	3	2
UCEC	eEF2 →	+0.334	+2.584	.010	.010	3	1
UCEC	EGFR_pY1068 →	-0.288	-2.736	.001	<.001	3	1
UCEC	eIF4E →	+0.181	+2.820	.019	.035	3	1
UCEC	A-Raf_pS299 →	-0.137	-2.222	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PCNA by TSG101 expression — UCEC

Explore this box plot interactively →