TSG101

Across TCGA cell cohorts, TSG101 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,544 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSG101-associated GO terms across cancer lineages are Exosomal secretion, DNA replication proofreading, and Type B pancreatic cell proliferation. Each is linked with TSG101 in more than 12 cancer types. Because this analysis shows association rather than direction, both TSG101-to-partner and partner-to-TSG101 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Exosomal secretion grouped by TSG101-low versus TSG101-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSG101→partner) and Y-score (partner→TSG101) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Exosomal secretion →	+0.148	+0.975	<.001	.001	3	13
OESOPHAGUS	DNA replication proofreading →	-0.192	-0.814	<.001	<.001	3	10
LUNG_SCLC	Type B pancreatic cell proliferation →	+0.216	+0.644	<.001	<.001	3	9
BONE	Synaptic vesicle cytoskeletal transport →	+0.075	+0.621	.001	.001	3	8
BONE	Synaptic vesicle transport along microtubule →	+0.075	+0.621	.001	.001	3	8
BLOOD_Myeloma	Negative regulation of protein localization to centrosome →	+0.111	+0.588	.009	.003	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,544 associations by consensus.

Exosomal secretion by TSG101 expression — OESOPHAGUS

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