TSG101

Across TCGA cell cohorts, TSG101 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TSG101-associated genes across cancer lineages are F9, OPRM1, and NEUROD4. Each is linked with TSG101 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSG101-to-partner and partner-to-TSG101 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F9 grouped by TSG101-low versus TSG101-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSG101→partner) and Y-score (partner→TSG101) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	F9 →	+0.035	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	OPRM1 →	+0.021	+4.523	.001	.004	3	1
BLOOD_Lymphoma	NEUROD4 →	+0.156	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	CFHR4 →	+0.190	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	PLCZ1 →	+0.127	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	RIPPLY1 →	+0.046	+4.191	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

F9 by TSG101 expression — BLOOD_Lymphoma

Explore this box plot interactively →