Across TCGA pan-cancer cohorts, TSEN15 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TSEN15 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TSEN15 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSEN15 expression acts as an unfavorable survival marker.

CCRCC, LSCC, and PDAC are the cancer types where TSEN15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.008	10	view →
LSCC	OS	Median	III,IV	0.689	1.000	.001	9	view →
PDAC	OS	Quartile	II,III,IV	0.776	0.936	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TSEN15 tumor-vs-normal RNA expression · all TSEN15 data types