Across TCGA pan-cancer cohorts, TSEN15 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TSEN15’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSEN15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSEN15 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
HNSC, COAD, and LIHC are the cancer types where TSEN15 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSEN15 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.