TSC22D1

Across TCGA patient cohorts, TSC22D1 mutation is significantly associated with the RNA expression of many other genes, with 2,221 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSC22D1-associated genes across cancer lineages are FOXO1B, RNU6-718P, and UHRF1. Each is linked with TSC22D1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSC22D1-to-partner and partner-to-TSC22D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO1B grouped by TSC22D1-low versus TSC22D1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC22D1→partner) and Y-score (partner→TSC22D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	FOXO1B →	+0.146	+5.039	<.001	.008	3	3
CESC	RNU6-718P →	+0.251	+6.584	<.001	<.001	3	2
UCEC	UHRF1 →	+0.766	+1.903	<.001	<.001	3	2
STAD	MIR5584 →	+0.765	+4.326	.001	.007	3	2
READ	RN7SL578P →	+0.172	+5.039	<.001	.008	3	2
LUSC	SLC16A14P1 →	+0.278	+3.750	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,221 associations by consensus.

FOXO1B by TSC22D1 expression — READ

Explore this box plot interactively →