TSC22D1

Across TCGA pan-cancer cohorts, TSC22D1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TSC22D1 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TSC22D1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TSC22D1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THCA show a favorable association.

KIRC, UVM, and ACC are the cancer types where TSC22D1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.722	0.532	<.001	169	view →
UVM	DFS	Median	All	0.392	0.787	<.001	154	view →
ACC	DFS	Quartile	All	0.202	0.760	<.001	62	view →
THCA	DFS	Tertile	All	0.936	0.769	<.001	52	view →
LGG	OS	Median	All	0.867	0.749	<.001	39	view →
COAD	OS	Tertile	IV	0.730	0.334	.001	31	view →
SCLC	DFS	Quartile	III,IV	0.142	0.591	.001	29	view →
OV	OS	Median	All	0.265	0.377	<.001	22	view →
LUSC	DFS	Tertile	All	0.908	0.696	.004	19	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
STAD	DFS	Quartile	All	0.392	0.771	.012	15	view →
MESO	OS	Median	All	0.447	0.633	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TSC22D1–KIRC (OS)

Open the KIRC breakdown →