TSC22D1

Across TCGA cell cohorts, TSC22D1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TSC22D1-associated genes across cancer lineages are H2BC1, TAAR8, and ASB17. Each is linked with TSC22D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSC22D1-to-partner and partner-to-TSC22D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by TSC22D1-low versus TSC22D1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC22D1→partner) and Y-score (partner→TSC22D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	H2BC1 →	+0.432	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	ASB17 →	+0.020	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	UMOD →	+0.004	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	UGT2A1 →	+0.538	+3.974	<.001	.005	3	1
LUNG_NSCLC_LUAD	GPR149 →	+0.385	+4.189	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

H2BC1 by TSC22D1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →