TSC22D1-AS1

Across TCGA pan-cancer cohorts, TSC22D1-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated TSC22D1-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher TSC22D1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSC22D1-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

UVM, HNSC, and ACC are the cancer types where TSC22D1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.561	0.913	<.001	137	view →
HNSC	DFS	Tertile	III,IV	0.783	0.591	<.001	69	view →
ACC	OS	Tertile	All	0.290	0.849	<.001	69	view →
PAAD	OS	Tertile	All	0.575	0.223	<.001	67	view →
MESO	OS	Median	All	0.300	0.472	.008	41	view →
SKCM	OS	Quartile	III,IV	0.589	0.249	.003	16	view →
BLCA	DFS	Tertile	All	0.272	0.576	.012	12	view →
KIRP	DFS	Median	II,III,IV	0.778	0.578	.015	12	view →
BRCA	DFS	Tertile	All	0.874	0.928	.004	12	view →
READ	OS	Median	IV	0.878	0.552	.016	12	view →
COAD	DFS	Quartile	All	0.326	0.698	.007	11	view →
LUSC	DFS	Quartile	III,IV	0.299	1.000	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

TSC22D1-AS1–UVM (DFS)

Open the UVM breakdown →