TSC2

Across TCGA patient cohorts, TSC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,202 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TSC2-associated proteins across cancer lineages are USP7, STAG2, and GTF3C4. Each is linked with TSC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TSC2-to-partner and partner-to-TSC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSC2 versus USP7 in COAD, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC2→partner) and Y-score (partner→TSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	USP7 →	+0.191	+0.579	<.001	<.001	3	4
GBM	STAG2 →	+0.295	+0.378	.006	<.001	3	4
LSCC	GTF3C4 →	+0.339	+0.391	.002	.004	3	4
LUAD	CRELD2 →	-0.426	-0.376	.001	<.001	3	4
GBM	FKBP11 →	-0.623	-0.350	<.001	<.001	3	4
BRCA	GLYR1 →	+0.232	+0.851	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,202 associations by consensus.

TSC2 vs USP7 — COAD

Explore this scatter interactively →