TSC2

Across TCGA patient cohorts, TSC2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSC2-associated genes across cancer lineages are IGFBP2, Caspase-7-cleavedD198, and ASNS. Each is linked with TSC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSC2-to-partner and partner-to-TSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by TSC2-low versus TSC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC2→partner) and Y-score (partner→TSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.595	-1.289	.004	.023	3	3
UCEC	Caspase-7-cleavedD198 →	+0.873	+2.341	<.001	<.001	3	3
STAD	ASNS →	+0.529	+2.115	.002	.017	3	2
STAD	Cyclin-E2 →	+0.105	+2.828	.049	.033	3	2
UCEC	ERK2 →	+0.218	+3.999	<.001	<.001	3	2
UCEC	Fibronectin →	-0.233	-1.523	.027	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

IGFBP2 by TSC2 expression — UCEC

Explore this box plot interactively →