TSC2

Across TCGA cell cohorts, TSC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,943 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSC2-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, Positive regulation of intracellular steroid hormone receptor signaling pathway, and mRNA splice site recognition. Each is linked with TSC2 in more than 17 cancer types. Because this analysis shows association rather than direction, both TSC2-to-partner and partner-to-TSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by TSC2-low versus TSC2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC2→partner) and Y-score (partner→TSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Calcium-independent cell-matrix adhesion →	+0.283	+1.431	<.001	<.001	3	18
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.210	+1.145	.001	.001	3	18
OESOPHAGUS	mRNA splice site recognition →	+0.141	+0.863	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.113	-0.893	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Nucleic acid catabolic process →	+0.061	+0.969	<.001	<.001	3	17
OVARY	Negative regulation of myoblast fusion →	+0.131	+0.936	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,943 associations by consensus.

Calcium-independent cell-matrix adhesion by TSC2 expression — BONE

Explore this box plot interactively →