TSC2

Across TCGA cell cohorts, TSC2 mutation is significantly associated with the RNA expression of many other genes, with 1,530 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSC2-associated genes across cancer lineages are EXOSC9, FEM1A, and E2F2. Each is linked with TSC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSC2-to-partner and partner-to-TSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOSC9 grouped by TSC2-low versus TSC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC2→partner) and Y-score (partner→TSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EXOSC9 →	+0.606	+3.346	<.001	.003	3	3
OVARY	FEM1A →	+0.705	+3.144	<.001	.007	3	3
BLOOD_Leukemia	E2F2 →	+1.547	+3.489	<.001	.001	3	3
BLOOD_Leukemia	EBF2 →	+0.141	+2.263	<.001	.006	3	3
SOFT_TISSUE	AVP →	+0.065	+3.977	<.001	.007	3	2
SOFT_TISSUE	KCNA6 →	+0.009	+3.295	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,530 associations by consensus.

EXOSC9 by TSC2 expression — BLOOD_Leukemia

Explore this box plot interactively →