TSC2

Across TCGA cell cohorts, TSC2 mutation is significantly associated with the mutation status of many other genes, with 5,474 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSC2-associated genes across cancer lineages are COL4A4, ALPK2, and ATG2B. Each is linked with TSC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TSC2-to-partner and partner-to-TSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL4A4 grouped by TSC2-low versus TSC2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC2→partner) and Y-score (partner→TSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	COL4A4 →	+4.000	+3.087	.008	.008	1	6
SOFT_TISSUE	ALPK2 →	+3.192	+3.392	.002	.002	1	6
CNS	ATG2B →	+3.762	+3.584	.003	.003	1	6
LARGE_INTESTINE	FRY →	+2.091	+1.917	<.001	<.001	1	6
UPPER_AERODIGESTIVE_TRACT	TNRC18 →	+2.731	+4.070	.009	.009	1	6
BREAST	MYCBP2 →	+2.637	+3.378	.004	.004	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,474 associations by consensus.

COL4A4 by TSC2 expression — OESOPHAGUS

Explore this box plot interactively →